https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53361 Wed 22 Nov 2023 12:59:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12136 Wed 11 Apr 2018 15:30:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43092 C] within intron 2 of the zinc finger protein 804A gene (ZNF804A) is associated with schizophrenia at the genome-wide level, but its function in relation to the development of psychotic disorders, including its influence on brain morphology remains unclear. Methods: Using both univariate (voxel-based morphometry, VBM; cortical thickness) and multivariate (source-based morphometry, SBM) approaches, we examined the effects of variation of the rs1344706 polymorphism on grey matter integrity in 214 Caucasian schizophrenia cases and 94 Caucasian healthy individuals selected from the Australian Schizophrenia Research Bank. Results: Neither univariate nor multivariate analyses showed any associations between indices of grey matter and rs1344706 variation in schizophrenia or healthy participants. This was revealed in the context of the typical pattern of decreased grey matter integrity in schizophrenia compared to healthy individuals, including: (1) large grey matter volume reductions in the orbitofrontal and anterior cingulate cortices and the left fusiform/inferior temporal gyri; (2) decreased cortical thickness in the left inferior temporal and fusiform gyri, the left orbitofrontal gyrus, as well as in the right pars opercularis/precentral gyrus; and (3) decreased covariation of grey matter concentration in frontal and limbic brain regions emerging from the SBM analyses. Conclusions: Contrary to some – but not all – previous findings, this study of a large sample of schizophrenia cases and healthy controls reveals no evidence for association between grey matter alterations and variation in rs1344706 (ZNF804A). Differences in sample sizes and ethnicities may account for discrepant findings between the present and previous studies.]]> Wed 07 Jun 2023 14:36:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33472 Wed 04 Sep 2019 09:48:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31487 Sat 24 Mar 2018 08:43:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5434 Sat 24 Mar 2018 07:48:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46407 n = 299) and healthy controls (n = 131), we observed that the MIR137 4-repeats VNTR (VNTR₄) variant was enriched in a cognitive deficit subtype of schizophrenia and associated with altered brain morphology, including thicker left inferior temporal gyrus and deeper right postcentral sulcus. These findings suggest that the MIR137 VNTR₄ may impact neuroanatomical development that may, in turn, influence the expression of more severe cognitive symptoms in patients with schizophrenia.]]> Mon 21 Nov 2022 11:38:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44169 Mon 10 Oct 2022 10:06:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48732 Fri 31 Mar 2023 09:37:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37996 Fri 23 Jul 2021 14:02:51 AEST ]]>